Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Does The Sinclair Method Work?
The Sinclair Method (TSM) is a medication-based treatment for alcohol use disorder (AUD) that involves taking naltrexone, an opioid antagonist, before drinking. This method was developed by Dr John David Sinclair and aims to reduce the pleasurable effects of alcohol, thereby helping individuals cut down or quit drinking over time.
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